Eligibility for Fecal Microbiota Transplantation (FMT)

Determining eligibility for Fecal Microbiota Transplantation (FMT) is crucial to ensure that this treatment is appropriate and safe for each individual patient. Below are the key criteria and considerations for determining eligibility for FMT.

1. General Eligibility Criteria

Recurrent Clostridium difficile Infection (CDI):

• Primary Indication: FMT is primarily used to treat patients with recurrent Clostridium difficile infections (CDI) that have not responded to standard antibiotic treatments.

• Frequency of Recurrence: Typically, candidates have experienced multiple episodes of CDI (usually three or more) despite receiving conventional therapies.

Failed Conventional Therapies:

• Previous Treatments: Patients should have undergone at least one or more rounds of antibiotic therapy, such as vancomycin or fidaxomicin, without achieving long-term resolution of CDI.

• Antibiotic Resistance: Evidence of persistent CDI or failure to respond to conventional treatments is a key factor in eligibility.

2. Specific Medical Conditions

Underlying Health Conditions:

• Assessing Co-morbidities: Patients with significant underlying health conditions or compromised immune systems may require additional evaluation to determine if FMT is appropriate.

• Consultation: A thorough medical assessment and consultation with a specialist are necessary to evaluate the risks and benefits of FMT in the context of any existing health conditions.

Pregnancy and Nursing:

• Pregnancy: FMT is generally not recommended for pregnant women due to potential risks to both the mother and the unborn child.

• Nursing: If breastfeeding, a detailed discussion with a healthcare provider is essential to understand any potential risks and considerations.

3. Exclusion Criteria

Active Infections:

• Other Infections: Patients with active infections other than CDI should address and resolve these conditions before undergoing FMT.

• Infection Control: Ensuring that all infections are properly managed is critical to prevent complications during and after the procedure.

Recent Gastrointestinal Surgery:

• Post-Surgical Status: Patients who have recently undergone major gastrointestinal surgery may need to wait until they have fully recovered before being considered for FMT.

• Surgical History: A complete surgical history should be reviewed to assess any potential impact on FMT outcomes.

Incompatible Donor Factors:

• Donor Screening: Eligibility also depends on the health and screening results of the fecal donor. Donors must meet strict health criteria to ensure the safety and efficacy of the transplant.

4. Evaluation Process

Initial Consultation:

• Healthcare Provider Consultation: Patients must have a detailed discussion with their healthcare provider to determine if FMT is the appropriate treatment option.

• Risk Assessment: A risk assessment will be conducted to evaluate the potential benefits and risks associated with FMT for the individual patient.

Medical History Review:

• Comprehensive Review: A thorough review of the patient's medical history, including past treatments and current health conditions, is essential to determine eligibility.

• Diagnostic Testing: Additional diagnostic testing may be required to confirm the appropriateness of FMT.

5. How to Proceed

Referral and Registration:

• Referral Process: Patients interested in FMT should obtain a referral from their primary care physician or specialist.

• Registration: After receiving a referral, patients may need to complete registration with an FMT provider or clinical network to initiate the treatment process.

Contact Information:

• For Questions and Further Information: If you have questions about eligibility or need more information about the FMT process, please contact our patient support team:

  • Email: patientsupport@fmt.life

  • Phone: 617-575-2201

  • Fax: 617-575-2201

We are here to assist you throughout your journey with FMT and ensure that you receive the most appropriate care tailored to your needs.